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Infectious Disease: Endemics

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Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine
Severe malaria is common in tropical countries in Africa, Asia, Oceania and South and Central America. It may also occur in travelers returning from endemic areas. Plasmodium falciparum accounts for most cases, although P vivax is increasingly found to cause severe malaria in Asia. Cerebral malaria is common in children in Africa, manifests as coma and seizures, and has a high morbidity and mortality. In other regions, adults may also develop cerebral malaria but neurological sequelae in survivors are rare.
Source: Journal of Critical Care - November 7, 2017 Category: Intensive Care Authors: Dilip R. Karnad, Mohd Basri Mat Nor, Guy A. Richards, Tim Baker, Pravin Amin, Council of the World Federation of Societies of Intensive and Critical Care Medicine Source Type: research

Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline.
Conclusions: Rapid, accurate diagnosis of fungal infections relies on appropriate application of laboratory testing, including antigen testing, serological testing, and PCR-based assays. PMID: 31469325 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - August 31, 2019 Category: Respiratory Medicine Authors: Hage CA, Carmona EM, Epelbaum O, Evans SE, Gabe LM, Haydour Q, Knox KS, Kolls JK, Murad MH, Wengenack NL, Limper AH Tags: Am J Respir Crit Care Med Source Type: research

Diagnosis of Lyme disease in the pediatric acute care setting
Purpose of review: We review the current evidence concerning the diagnosis of Lyme disease in children for application in the acute care setting. Recent findings: Recent studies suggest that Lyme disease incidence is substantially higher than previously described. Although efforts are ongoing to identify alternative testing strategies, two-tiered serologic testing remains the diagnostic standard in children with compatible clinical syndromes. Published clinical prediction rules can assist clinicians caring for children with potential Lyme disease. Summary: Two-tiered serologic testing remains the mainstay of the diagnosi...
Source: Current Opinion in Pediatrics - May 3, 2016 Category: Pediatrics Tags: EMERGENCY AND CRITICAL CARE MEDICINE: Edited by Jean Klig and Clifford W. Bogue Source Type: research

Anticipated and unanticipated complications of severe dengue in a primigravida
We present the successful management of hemorrhage and unanticipated complications of severe dengue in a young primigravida admitted to the Intensive Care Unit after an emergency cesarean section.
Source: Indian Journal of Critical Care Medicine - November 10, 2015 Category: Intensive Care Authors: Madiha HashmiGhulam ZainabFarah Khan Source Type: research

Melioidosis: An emerging infection with fatal outcomes
We present a rare case of melioidosis with rapid disease progression to fatal outcome from Chennai, South India.
Source: Indian Journal of Critical Care Medicine - June 15, 2017 Category: Intensive Care Authors: Isabella Princess R Ebenezer Nagarajan Ramakrishnan Arun Kumar Daniel S Nandini MA Thirunarayan Source Type: research

Clinically lesser known entity in India: A Report of two cases of Melioidosis
Purabi Barman, Ravneet Kaur, Kamlesh KumarIndian Journal of Critical Care Medicine 2013 17(1):46-48Melioidosis is endemic in the South Asian regions, like Thailand, Singapore Malaysia and Australia. The disease is more pronounced in the southern part of the country. It is caused by Burkholderia pseudomallei which causes systemic involvement, morbidity and mortality associated with the disease is high. Due to highly varied clinical presentation, and low general awareness this infection is largely underdiagnosed and under reported in our country. Most laboratories in the country still rely on conventional culturing methods w...
Source: Indian Journal of Critical Care Medicine - May 17, 2013 Category: Intensive Care Authors: Purabi BarmanRavneet KaurKamlesh Kumar Source Type: research

Procalcitonin levels in salmonella infection
Conclusion: PCT levels in Salmonella infections are near normal or minimally increased which differentiates it from other systemic Gram-negative infections. PCT cannot be used as a specific diagnostic marker of typhoid.
Source: Indian Journal of Critical Care Medicine - August 7, 2015 Category: Intensive Care Authors: Vikas MishraJehangir Sorabjee Source Type: research

Fatal postoperative hemolysis due to severe falciparum malaria
Amol T Kothekar, Vijaya Patil, Nambiraj Konar, Jigeeshu DivatiaIndian Journal of Critical Care Medicine 2017 21(6):391-393A 60-year-old apparently healthy female patient underwent mastectomy for breast cancer. She had sinus tachycardia and no other abnormal finding in the preoperative period. However, the immediate postoperative course was stormy with the development of anemia, thrombocytopenia, hemolysis, and renal failure with severe metabolic acidosis. Peripheral blood smear revealed the presence of ring forms of Plasmodium falciparum. Multiorgan failure and death occurred within 36 h of surgery in spite of initiation o...
Source: Indian Journal of Critical Care Medicine - June 15, 2017 Category: Intensive Care Authors: Amol T Kothekar Vijaya Patil Nambiraj Konar Jigeeshu Divatia Source Type: research

Leptospirosis: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine
Leptospirosis is a zoonosis caused by a gram negative aerobic spirochete of the genus Leptospira. It is acquired by contact with urine or reproductive fluids from infected animals, or by inoculation from contaminated water or soil. The disease has a global distribution, mainly in tropical and subtropical regions that have a humid, rainy climate and is also common in travelers returning from these regions. Clinical suspicion is critical for the diagnosis and it should be included in the differential diagnosis of any patient with a febrile hepatorenal syndrome in, or returning from endemic regions.
Source: Journal of Critical Care - November 2, 2017 Category: Intensive Care Authors: Juan Ignacio Silesky Jim énez, Jorge Luis Hidalgo Marroquin, Guy A. Richards, Pravin Amin Source Type: research

Melioidosis Causing Critical Illness: A Review of 24 Years of Experience From the Royal Darwin Hospital ICU*
Objectives: Melioidosis is increasing in incidence with newly recognized foci of melioidosis in the Americas, Africa, and elsewhere. This review describes the demographics, management, and outcomes of a large cohort of critically ill patients with melioidosis. Design: Data were extracted from two prospective databases—the Menzies School of Health Research Melioidosis Database (1989–2013) and the Royal Darwin Hospital ICU Melioidosis Database (2001–2013). Setting and Patients: The Royal Darwin Hospital ICU is the only ICU in the tropical Top End of Northern Territory of Australia, an endemic area for melioidosis. Th...
Source: Critical Care Medicine - July 19, 2016 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Dengue fever: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine
Dengue is an arbovirus affecting humans and spread by mosquitoes. Severe dengue follows a secondary infection with a different virus serotype. The problem is truly global as it is endemic in over 100 countries. Severe dengue can be a life-threatening because of increased vascular permeability, resulting in leakage of fluid from the intravascular compartment to the extravascular space. When major bleeding does occur, it is almost invariably combined with profound shock since this, in combination with thrombocytopenia, hypoxia, and acidosis, can lead to multiple organ failure and disseminated intravascular coagulation.
Source: Journal of Critical Care - November 5, 2017 Category: Intensive Care Authors: Pravin Amin, Özlem Acicbe, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Tim Baker, Guy A. Richards Source Type: research

Fulminant dengue myocarditis requiring VA ECMO support
Publication date: Available online 28 December 2018Source: The Egyptian Journal of Critical Care MedicineAuthor(s): Nanda Kishor Vuppali, Abhinav Pandey, Rushita Torkadi, Pallapotu Sandya, Ramadoss Nagarajan, Dharmapuram Anil Kumar, Sudeep VarmaAbstractDengue is endemic disease in India and tropical countries. It has a wide spectrum of presentation varying from asymptomatic to manifest as undifferentiated fever, dengue fever, dengue shock syndrome or dengue haemorrhagic fever. An increasing number of cases of dengue are being reported with atypical presentations such as dengue encephalitis, secondary bacterial infections, ...
Source: The Egyptian Journal of Critical Care Medicine - December 29, 2018 Category: Intensive Care Source Type: research

The Dynamics of QuantiFERON®-TB Gold In-Tube Conversion and Reversion in a Cohort of South African Adolescents.
Conclusions. In this tuberculosis-endemic setting, annual risk of infection was extremely high, while QFT and TST conversion concordance were higher and QFT reversion rates were lower than reported from low-burden settings. PMID: 25562578 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 6, 2015 Category: Respiratory Medicine Authors: Andrews JR, Hatherill M, Mahomed H, Hanekom WA, Campo M, Hawn TR, Wood R, Scriba TJ Tags: Am J Respir Crit Care Med Source Type: research

Dose Optimization of H56:IC31 Vaccine for TB Endemic Populations: A Double-Blind, Placebo-Controlled, Dose-Selection Trial.
CONCLUSIONS: Two or three H56:IC31 vaccinations at the lowest dose induced durable antigen-specific CD4 T cell responses with acceptable safety and tolerability profiles in M.tb-infected and uninfected adults. Additional studies should validate applicability of vaccine doses and regimens to both QFT-positive and negative individuals. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01865487. PMID: 30092143 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - August 9, 2018 Category: Respiratory Medicine Authors: Suliman S, Luabeya AKK, Geldenhuys H, Tameris M, Hoff ST, Shi Z, Tait D, Kromann I, Ruhwald M, Rutkowski KT, Shepherd B, Hokey D, Ginsberg AM, Hanekom WA, Andersen P, Scriba TJ, Hatherill M, H56-035 Trial Group Tags: Am J Respir Crit Care Med Source Type: research

Higher Rates of Misdiagnosis in Pediatric Patients Versus Adults Hospitalized With Imported Malaria
Conclusions: Pediatric patients admitted for imported malaria at Montefiore Medical Center had a higher rate of misdiagnosis and presented with more gastrointestinal symptoms than hospitalized adults. By describing the clinical characteristics of patients with imported malaria, we hope to improve diagnostic accuracy by health care workers and raise awareness that friends and relatives may require more intensive pretravel counseling.
Source: Pediatric Emergency Care - April 1, 2016 Category: Emergency Medicine Tags: Original Articles Source Type: research